Name (abbrev)

Name (full)

Category

Last update

drugs

Molecular Biology

b D, Y

Application domain

Further specifications

Learning Drug Structure-Activity Rules for Suramin Analogues

Type

Format

Complexity

ILP

Progol

23KB

WWW / FTP

Contact person(s)

Related group(s)

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References

Braddock, P. S., D.-E. Hu, et al. (1994).
A structure-activity analysis of the growth factor and angiogenic
activity of basic fibroblast growth factor by suramin and related
polyanions.
in Br. J. Cancer. 69: 890-898.

Annotations

Suramin analogues act as anti-cancer agents by interfering with the formation of blood vessels for the tumor. Using the atomic structure and bond relationships present in suramin compounds, the task for an ILP system is to discover structural features that can be used to improve such compounds. Formally, this goal is closely related to the problem studied in connection with the Alzheimer's disease. The used data are taken from [Braddock], their structure and the language applied are closely related to the Alzheimer's case.

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